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在心力衰竭心功能减退的调节中,心室后负荷重要性的新近认识,导致了对严重慢性充血性心力衰竭患者血管张力亢进的机制产生了极大的兴趣.体循环血管扩张剂治疗难治性心功能不全已变得非常流行.通过广泛应用这些血管扩张剂而迅速积累的知识,显示了肾素-血管紧张素-醛固酮系统在心力衰竭病理生理中的特殊重要性.口服长效血管紧张素转化酶抑制剂——巯甲丙脯氨酸,通过阻碍缩血管肽血管紧张素的产生,提供了一种降低后负荷的简单方法.可以预期,这种血管紧张素转化酶抑制剂的药物动力学
In the regulation of heart failure hypokalemia, the recent understanding of the importance of post-ventricular postload has led to great interest in the mechanism of vascular tone hyperfunction in patients with severe chronic congestive heart failure. Circulating Vasodilators for the Treatment of Refractory Heart Insufficiency of function has become very popular and the rapid accumulation of knowledge of these widely used vasodilators shows the particular importance of the renin-angiotensin-aldosterone system in the pathophysiology of heart failure.Long-acting oral angiotensin-converting The enzyme inhibitor, captopril, provides a simple way to reduce postload by blocking the production of angiotensin, a vasoconstrictor.It is expected that the pharmacokinetics of this angiotensin-converting enzyme inhibitor