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甲状腺激素过多刺激肝脏合成胆固醇和甘油三脂,但甲状腺功能亢进症(甲亢)对脂蛋白代谢的主要影响是增加从循环中清除低密度脂蛋白、极低密度脂蛋白和高密度脂蛋白,导致血清胆固醇、甘油三脂、β-脂蛋白和高密度脂蛋白—胆固醇浓度下降。资料与方法本组40例甲亢患者,男性12例,女性28例。年龄16～61岁,平均为36岁。40例中除2例为毒性结节性甲状腺肿外,均为Graves病。其中初发25例,复发15例。病程2个月至8年,平均为4.5个月。全部患者均除外糖尿病,高血压和家族性高脂血症。治疗前测定血清总T_3、总T_4、总胆固醇、β-脂蛋白、甘油三脂和高密度脂蛋白—胆固醇。全部患者经抗甲状腺药物治疗2个月左右,高代谢症群控制,总T_3
Thyroid hormone excess stimulates the liver to synthesize cholesterol and triglycerides, but the major effects of hyperthyroidism on lipoprotein metabolism are increased clearance of low density lipoprotein, very low density lipoprotein and high density lipoprotein from the circulation, Leading to a decrease in serum cholesterol, triglycerides, beta-lipoprotein and high-density lipoprotein-cholesterol concentrations. Materials and Methods The group of 40 patients with hyperthyroidism, 12 males and 28 females. Age 16 to 61 years old, with an average of 36 years old. In 40 cases except for 2 cases of toxic nodular goiter, are Graves disease. Including 25 cases of initial, recurrence in 15 cases. Course of 2 months to 8 years, with an average of 4.5 months. All patients except diabetes, hypertension and familial hyperlipidemia. Before treatment, total serum T 3, total T 4, total cholesterol, β-lipoprotein, triglyceride and high density lipoprotein-cholesterol were measured. All patients were treated with anti-thyroid drugs for about 2 months, high metabolic group control, total T_3