自Chong在1995年发现人端粒重复序列结合因子hTRF1后,近几年已发现了包括Tankyrase、TRF2、TIN2、PIN2等近10种端粒结合蛋白,对它们的结构和功能也有了更深的了解。现在认为hTRF1等端粒结合蛋白与端粒一起形成三维环状结构t-loop,在这一复合结构中端粒结合蛋白和端粒、端粒酶相互作用,共同完成对细胞基本生命活动的调节,与衰老和肿瘤也有着密切的联系。展开和深入对该领域的研究不但可以解决这些问题,也对了解衰老和肿瘤的根本机制和进一步寻求诊断和治疗的途径具有十分重要的意义。本文就端粒结合蛋白在近几年的研究进展进行综述。 Since Chong discovered the human telomere repeat binding factor hTRF1 in 1995, nearly ten telomere binding proteins including Tankyrase, TRF2, TIN2 and PIN2 have been found in recent years, and their structures and functions have been further understood . It is now believed that telomere binding proteins such as hTRF1 and telomere together form a three-dimensional cyclic t-loop in which the telomere binding protein interacts with telomeres and telomerase to accomplish the regulation of basic cell life activities , And aging and cancer are also closely linked. Expanding and furthering the research in this field can not only solve these problems, but also understand the fundamental mechanisms of aging and cancer and further seek ways of diagnosis and treatment is of great significance. This review summarizes the progress of telomere binding proteins in recent years.