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目的探讨尿微量清蛋白(urine microalbumin,U-m Alb)在糖尿病肾病(diabetic nephropathy,DN)患者临床诊断中的价值。方法选择确诊为DN患者50例作为DN组,诊断为2型糖尿病(type 2 diabetes mellitus,T2DM)的患者50例作为T2DM组,50名健康人群作为正常组;分别对各组的U-m Alb、血清肌酐(serum creatinine,Scr)、尿素(Urea)、Hb A1c进行检测,比较三组受试者各项检测指标的差异。三组计量资料比较采用方差分析,两两比较采用LSD-t检验,P<0.05为差异有统计学意义。结果三组Urea、Scr、U-m Alb、Hb A1c水平比较,差异均有统计学意义(F=9.963、12.435、15.901、13.324,均P<0.05),两两比较发现,DN组与T2DM组的Urea、Scr、U-m Alb、Hb A1c水平相比,差异均有统计学意义(均P<0.05);而DN组仅与正常组的U-m Alb、Hb A1c水平比较,差异有统计学意义(P<0.05);T2DM组与正常组的Urea、Scr、U-m Alb、Hb A1c水平比较,差异均有统计学意义(均P<0.05)。结论 U-m Alb测定能够使DN患者及时得到诊断。
Objective To investigate the clinical value of urine microalbumin (U-m Alb) in the diagnosis of diabetic nephropathy (DN). Methods Fifty patients with DN were selected as DN group and 50 patients with type 2 diabetes mellitus (T2DM) as T2DM group and 50 healthy individuals as normal group. The serum levels of Um Alb, Serum creatinine (Scr), urea (Urea) and Hb A1c were detected, and the differences among the three test groups were compared. The three groups of measurement data were compared using analysis of variance, pairwise comparison using LSD-t test, P <0.05 for the difference was statistically significant. Results There was significant difference in the levels of Urea, Scr, Um Alb and Hb A1c among the three groups (F = 9.963,12.435,15.901,13.324, all P <0.05) (P <0.05), while there was significant difference between DN group and Um Alb, Hb A1c levels in normal group (P <0.05) ). There was significant difference in the levels of Urea, Scr, Um Alb and Hb A1c between T2DM group and normal group (all P <0.05). Conclusion The U-m Alb assay can prompt DN patients to be diagnosed promptly.