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将药物及高分子材料溶于乙醇后边搅拌边加入非溶剂制成布洛芬－聚丙烯酸树脂Ⅱ共沉淀物。通过Ａ、Ｂ两种方法并以不同的药物－聚丙烯酸树脂Ⅱ比例制成了共沉淀物，再以这些共沉淀物直接压片制成骨架片。通过差热分析（ＤＳＣ）、扫描电镜（ＤＳＣ）及红外光谱（ＩＲ）研究了共沉淀物的性质。研究主要集中在处方中高分子材料所占的比例，溶出介质的ｐＨ及制备共沉淀物的方法对布洛芬从骨架中释放的影响。体外溶出实验分别在不同的ｐＨ条件下进行。处方研究表明随着聚丙烯酸树脂Ⅱ用量的增加，药物的释放过程显著延长。另外，增加溶出介质的ｐＨ会显著增加药物的累积释放百分数。此外实验还表明以方法Ｂ制成的共沉淀物的骨架片中药物的累积释放百分数要高于Ａ法制成的骨架片，然而方法Ａ中制得的骨架片中药物的释放却更接近于线性释放。
The drug and polymer materials were dissolved in ethanol after stirring while adding non-solvent ibuprofen - polyacrylic resin Ⅱ coprecipitate. By A, B two methods and different drugs - polyacrylic resin Ⅱ ratio made of coprecipitate, and then these coprecipitates directly into tablets made of matrix. The properties of coprecipitates were investigated by differential thermal analysis (DSC), scanning electron microscopy (DSC) and infrared spectroscopy (IR). The main research focuses on the proportion of the polymer material in the prescription, the pH of the dissolution medium and the method of preparing the coprecipitate on the release of ibuprofen from the framework. In vitro dissolution experiments were carried out at different pH conditions. Prescription studies show that with the increase in the amount of polyacrylic resin Ⅱ, the drug release process was significantly prolonged. In addition, increasing the pH of the dissolution medium can significantly increase the cumulative drug release percentage. In addition, experiments also showed that the cumulative release percentages of the drug in the matrix pellets prepared by Method B were higher than those of the matrix A method, whereas the drug release in the matrix A method was more linear freed.