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小细胞肺癌存活者患第二个原发癌的危险性增加已有报道。治疗对发生第二个原发癌的作用很难评价,部分原因是由于任何一个研究所长期存活的病例数都很少。作者设计了一个多研究所参加的研究计划,以调查发生不同于小细胞肺癌的第二个原位癌的危险性。
The increased risk of second primary cancer among survivors of small cell lung cancer has been reported. The effect of treatment on the occurrence of a second primary cancer is difficult to assess, partly because of the small number of long-term survivors in any one institution. The authors designed a multi-institutional research program to investigate the risk of developing a second carcinoma in situ that is different from small cell lung cancer.