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目的探讨分析冠心病(Coronary heart disease,CHD)合并糖尿病(Diabetes mellitus,DM)患者胰岛素抵抗(Insulin Resistance,IR)及其抵抗素(Resistin,RE)的相关性。方法入选2010年9月至2010年12月住院的冠心病合并糖尿病患者60例,入选同期住院的单纯冠心病患者60例,另取健康对照组50例。采用酶联免疫吸附测定(ELISA)法检测各组的血清RE,空腹血糖及空腹胰岛素,用后二者计算胰岛素抵抗指数(Insulin Resistance Index,IRI)。结果与健康对照组比较,冠心病合并糖尿病组及冠心病组血清RE﹑IRI均升高;冠心病合并糖尿病组较冠心病组血清RE﹑IRI升高;相关性分析显示升高的RE与升高的IRI正相关。结论冠心病合并糖尿病患者IRI及RE高于冠心病患者;冠心病患者IRI及RE高于健康对照组。RE与IR呈正相关。
Objective To investigate the relationship between insulin resistance (IR) and resistin (Resistin, RE) in patients with coronary heart disease (CHD) and diabetes mellitus (DM). Methods Sixty patients with coronary heart disease and diabetes admitted to hospital from September 2010 to December 2010 were enrolled in the study. 60 patients with simple coronary heart disease and 50 healthy controls were enrolled in the same period. Serum RE, fasting blood glucose and fasting insulin in each group were detected by enzyme linked immunosorbent assay (ELISA), and insulin resistance index (IRI) was calculated using the latter two. Results Compared with the healthy control group, serum RE ﹑ IRI in coronary heart disease complicated with diabetes mellitus and coronary heart disease group were increased; serum RE ﹑ IRI in coronary heart disease complicated with diabetes mellitus group was higher than that in coronary heart disease group; correlation analysis showed that elevated RE and L High IRI is positively correlated. Conclusion IRI and RE in patients with coronary heart disease complicated with diabetes are higher than those in patients with coronary heart disease. IRI and RE in patients with coronary heart disease are higher than those in healthy controls. RE and IR were positively correlated.