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目的了解HIV/AIDS患者治疗前后补体C1q水平及相关实验室指标检测结果的变化情况。方法选取2011-09~2014-10在广西艾滋病临床治疗中心(南宁)进行抗逆转录病毒治疗的患者共96例。观察所有病例处于基线时和治疗6个月后血清补体C1q水平及其他相关实验室指标检测结果变化情况。结果 HIV/AIDS患者抗病毒治疗后补体C1q总浓度水平比治疗前降低,差异具有统计学意义(P<0.05);治疗后补体C1q浓度升高者33例,不变或降低者63例,升高例数和降低例数比较差异具有统计学意义(P<0.05);治疗后6个月CD3、CD4、CD8、CD4/CD8、病毒载量检测结果与治疗前比较,CD3、CD4、CD8、CD4/CD8的检测结果升高,病毒载量的检测结果降低,差异具有统计学意义(P<0.01)。结论 HIV/AIDS患者治疗前后联合检测补体C1q水平及相关实验室指标对指导临床治疗具有重要的意义。
Objective To understand the changes of complement C1q levels and related laboratory indexes before and after treatment in HIV / AIDS patients. Methods A total of 96 patients with antiretroviral therapy in Guangxi AIDS Clinical Treatment Center (Nanning) from 2011-09 to 2014-10 were selected. All cases were observed at baseline and 6 months after treatment of serum complement C1q levels and other related laboratory indicators test results change. Results The total level of C1q in patients with HIV / AIDS was lower than that before treatment (P <0.05). After the treatment, the level of complement C1q was increased in 33 patients, unchanged or decreased in 63 patients, (P <0.05). The levels of CD3, CD4, CD8, CD4 / CD8, and viral load at 6 months after treatment were significantly lower than those before treatment CD4 / CD8 test results increased, the detection of viral load decreased, the difference was statistically significant (P <0.01). Conclusions The combined detection of complement C1q levels and related laboratory parameters in HIV / AIDS patients before and after treatment is of great significance to guide the clinical treatment.