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目的探讨局部晚期宫颈癌(Ⅰb～Ⅲb期)介入治疗(动脉内灌注化疗)的临床疗效及影响因素。资料与方法 53例局部晚期宫颈癌行以顺铂为主的动脉内灌注化疗,评估介入治疗的临床疗效并统计分析不同疗效患者的年龄、临床分期、肿瘤大小、肿瘤分级、病理类型、盆腔淋巴转移、血红蛋白(Hb)水平、生存时间。结果 40例患者动脉内灌注化疗临床有效,临床有效率75.5%。临床分期(P=0.018)、肿瘤大小(P=0.003)、术前Hb水平(P=0.013)对动脉内灌注化疗疗效影响显著;多因素Logistic回归显示,肿瘤大小是影响介入疗效的独立因素(P=0.002);介入治疗有效者生存时间明显延长(Kaplan-Meier法,Log rank,P=0.000)。结论新辅助动脉内灌注化疗对局部晚期宫颈癌有明显疗效,肿瘤大小、临床分期、血红蛋白水平影响介入治疗疗效。
Objective To investigate the clinical efficacy and influencing factors of interventional therapy (intra-arterial infusion chemotherapy) in locally advanced cervical cancer (stage Ⅰb-Ⅲb). Materials and Methods 53 patients with locally advanced cervical cancer underwent intra-arterial chemotherapy with cisplatin as the predictor. The clinical effects of interventional therapy were evaluated and the age, clinical stage, tumor size, tumor grade, pathological type, Metastasis, hemoglobin (Hb) level, survival time. Results 40 cases of intra-arterial infusion chemotherapy clinically effective clinical effective rate of 75.5%. The clinical stage (P = 0.018), tumor size (P = 0.003) and preoperative Hb level (P = 0.013) had significant effects on the efficacy of intra-arterial infusion chemotherapy. Multivariate Logistic regression showed that tumor size was an independent factor influencing interventional efficacy P = 0.002). The survival time was significantly longer in the intervention group (Kaplan-Meier method, Log rank, P = 0.000). Conclusion Neoadjuvant artery infusion chemotherapy has obvious curative effect on locally advanced cervical cancer. The size of tumor, clinical stage and hemoglobin level affect the effect of interventional therapy.