喉癌是耳鼻咽喉-头颈外科常见恶性肿瘤之一,近年来喉癌的发病率有明显增多的趋势,且发病年龄趋于年轻化,其主要病理类型为鳞状细胞癌。研究表明肿瘤的发生与细胞周期的调控异常有密切的关系〔1〕。细胞周期蛋白(cyclin)是真核细胞周期循环中主要的调节因子,与细胞癌变关系十分 Laryngeal cancer is one of the most common malignant tumors of the otorhinolaryngology-head and neck surgery. In recent years, the incidence of laryngeal cancer has obviously increased, and the age of onset tends to be younger. Its main pathological type is squamous cell carcinoma. Studies have shown that the occurrence of tumors and cell cycle regulation is closely related to the abnormal 〔1〕. Cyclin is a major regulator of the cycle of eukaryotic cells and has a very close relationship with cancerous cells