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目的观察TP(紫杉醇+顺铂)方案联合腹腔镜子宫切除术治疗宫颈癌的临床疗效。方法2010年4月至2013年11月收治103例经病理确诊为Ib2~IIa期宫颈癌患者,按随机数字表法分为对照组(n=52)和观察组(n=51)。对照组给予腹腔镜下广泛全子宫切除术和盆腔淋巴结清扫术常规治疗,观察组给予TP方案联合腹腔镜下广泛全子宫切除术和盆腔淋巴结清扫术综合治疗。观察并比较两组患者近期临床疗效及术后病理变化的差异。结果观察组总有效率84.31%明显优于对照组(57.69%),差异具有统计学意义(P<0.05);治疗组术后脉管浸润率7.84%、宫颈深肌层浸润率37.25%、盆腔淋巴结转移率23.53%,均明显优于对照组(19.23%、65.38%、55.77%),差异具有统计学意义(P均<0.05)。结论 TP方案联合腹腔镜子宫切除术治疗宫颈癌的临床疗效显著。
Objective To observe the clinical efficacy of TP (paclitaxel + cisplatin) combined with laparoscopic hysterectomy in the treatment of cervical cancer. Methods From April 2010 to November 2013, 103 patients with pathologically confirmed cervical cancer of stage Ib2 - IIa were enrolled and divided into control group (n = 52) and observation group (n = 51) according to random number table. The control group was given laparoscopic radical hysterectomy and pelvic lymphadenectomy routine treatment, the observation group given TP program combined with laparoscopic radical hysterectomy and pelvic lymph node dissection comprehensive treatment. To observe and compare the two groups of patients with short-term clinical efficacy and postoperative pathological changes. Results The total effective rate in observation group was 84.31%, which was significantly higher than that in control group (57.69%), the difference was statistically significant (P <0.05). The vascular invasion rate in treatment group was 7.84%, deep myometrial invasion rate was 37.25% The lymph node metastasis rate was 23.53%, which was significantly better than that of the control group (19.23%, 65.38%, 55.77%), the difference was statistically significant (all P <0.05). Conclusion TP regimen combined with laparoscopic hysterectomy for the treatment of cervical cancer significant clinical effect.