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目的:探讨超敏C-反应蛋白(hsCRP)、肿瘤坏死-α(TNF-α)、白细胞介素-10(IL-10)对小儿败血症的早期诊断价值。方法:选择临床诊断为败血症患儿57例和同期无感染征象的小儿36例,采用双抗体夹心ELISA法检测血清TNF-α,IL-10的水平,采用速率散射比浊法测定hsCRP。结果:hsCRP、IL-10和TNF-α在败血症组和对照组有显著意义。hSCRP有较高的特异度;TNF-α的敏感度是最高的。联合诊断时hsCRP和TNF-α的临床诊断价值最高。结论:hsCRP、IL-10和TNF-α对小儿败血症的早期诊断有一定价值;hsCRP和TNF-α是最佳的联合诊断指标之一。
Objective: To investigate the early diagnostic value of hsCRP, TNF-α and IL-10 in pediatric sepsis. Methods: Totally 57 children with sepsis and 36 children without infection were enrolled in this study. Serum TNF-α and IL-10 levels were measured by sandwich ELISA. The hsCRP was measured by rate nephelometry. Results: The levels of hsCRP, IL-10 and TNF-α in sepsis group and control group were significant. hSCRP has a higher specificity; TNF-α sensitivity is the highest. The combined diagnosis of hsCRP and TNF-α clinical diagnosis of the highest value. Conclusion: hsCRP, IL-10 and TNF-α have some value in the early diagnosis of pediatric sepsis. HsCRP and TNF-α are the best diagnostic indexes.