论文部分内容阅读
纳洛酮对昏迷患者具有显著的促醒作用[1 3 ] ,一般认为纳洛酮可拮抗内源性阿片肽[4] 。纳洛酮促醒的机制并非这样简单。我们研究了纳洛酮对大鼠额叶皮质 (FCX)锥体细胞兴奋性的影响 ,进而阐明纳洛酮促醒的神经药理机制。材料和方法 :选取 8～ 12dWistar大鼠。将大鼠的额叶前端
Naloxone has a significant role in arousal in patients with coma [13], naloxone is generally believed to antagonize endogenous opioid peptides [4]. The mechanism of naloxone arousal is not that simple. We investigated the effects of naloxone on the excitability of the rat frontal cortex (FCX) pyramidal cells and elucidated the neuropharmacological mechanisms of naloxone arousal. Materials and Methods: Eight to 12 days Wistar rats were selected. The frontal lobe of the rat will be