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目的 探讨糖皮质激素治疗对传染性非典型肺炎(SARS)患者糖代谢的影响。方法 将214例SARS患者分为激素组(H)和非激素组(NH);筛选与血糖水平有关的因素,进行多元回归分析。结果H组空腹血糖(FBG)显著高于NH组(P<0.001);H组中甲泼尼龙(M)、泼尼松(P)或两药混用(M+P)对FBG的影响有显著性差异(P<0.001),M>M+P>P;FBG水平与患者年龄、激素日均剂量存在正相关(P<0.001)。结论糖皮质激素治疗使SARS患者糖代谢受损。
Objective To investigate the effect of glucocorticoid therapy on glycometabolism in patients with SARS. Methods 214 cases of SARS patients were divided into hormone group (H) and non-hormone group (NH). The factors related to blood glucose level were screened and multivariate regression analysis was performed. Results The fasting blood glucose (FBG) in group H was significantly higher than that in group NH (P <0.001). The effect of methylprednisolone (M), prednisone (P) or combination of two drugs on FBG in group H was significant (P <0.001), M> M + P> P. There was a positive correlation between the level of FBG and patient’s age and daily dose of hormone (P <0.001). Conclusion Glucocorticoid treatment impaired glucose metabolism in SARS patients.