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目的探讨糠酸莫米松鼻喷雾剂联合玉屏风颗粒治疗季节性变应性鼻炎临床疗效。方法选取2014年7月至2015年6月因季节性变应性鼻炎在南京市第一医院接受治疗的128例患者作为研究对象,按照就诊时间的先后顺序分为两组,各64例,其中,试验组予糠酸莫米松鼻喷雾剂联合玉屏风颗粒治疗,对照组予糠酸莫米松鼻喷雾剂治疗,观察并对比分析两组患者的临床疗效、症状和体征、不良反应以及预后等。结果试验组治疗总有效率为92.19%,对照组为79.69%,试验组治疗总有效率明显高于对照组,差异有统计学意义(χ2=4.137,P=0.042);入院时,两组患者症状评分和体征评分比较,差异无统计学意义(P均>0.05),随着治疗时间的延长,两组患者的症状评分和体征评分均呈下降趋势,差异有统计学意义(P均<0.01),在治疗第2、4、12周时,试验组症状和体征评分均低于对照组(P均<0.01);除个别患者出现鼻部刺激感以及局限性鼻出血外,两组患者均未出现严重的不良反应;随访1年,对照组复发率为17.19%,试验组复发率为14.06%,两者复发率比较,差异无统计学意义(χ2=0.237,P=0.626)。结论糠酸莫米松鼻喷剂联合玉屏风颗粒治疗季节性变应性鼻炎具有显著的临床疗效,能快速、高效的改善患者的临床症状和体征,同时无明显严重的不良反应。
Objective To investigate the clinical efficacy of mometasone furoate nasal spray combined with Yupingfeng granule in the treatment of seasonal allergic rhinitis. Methods From July 2014 to June 2015, 128 patients with seasonal allergic rhinitis treated in the First Hospital of Nanjing City were selected as the study subjects and divided into two groups according to the order of their visiting time: 64 cases . The experimental group was treated with mometasone furoate nasal spray combined with Yupingfeng granule and the control group with mometasone furoate nasal spray. The clinical efficacy, symptoms and signs, adverse reactions and prognosis of the two groups were observed and compared. Results The total effective rate was 92.19% in the experimental group and 79.69% in the control group. The total effective rate in the experimental group was significantly higher than that in the control group (χ2 = 4.137, P = 0.042) There was no significant difference between the symptom score and the sign score (P> 0.05). With the extension of the treatment time, the symptom score and the sign score of both groups showed a downward trend, the difference was statistically significant (P <0.01) ). At the 2nd, 4th and 12th week of treatment, the scores of symptoms and signs in the experimental group were lower than those in the control group (all P <0.01). Except for the nasal irritation and the limited nasal hemorrhage in some patients, There was no serious adverse reaction. One year follow-up, the recurrence rate was 17.19% in the control group and 14.06% in the experimental group. There was no significant difference in recurrence rate between the two groups (χ2 = 0.237, P = 0.626). Conclusion Mometasone furoate nasal spray combined with Yupingfeng granule has significant clinical curative effect on seasonal allergic rhinitis, which can quickly and efficiently improve the clinical symptoms and signs of patients without obvious serious adverse reactions.