本文报告两例口腔白色损害临床诊断为扁平苔藓的患者,给予保守治疗.一年内皮疹形态发生改变,经活检诊断为念珠菌性粘膜白斑,而后又均在原发疹的部位产生鳞状细胞癌.例一:35岁,妇女.主诉颊粘膜出现水疱5个月,舌肿胀一个月.先前健康状况很好,没有任何皮肤病.她每天仅抽3～4支香烟,偶尔饮酒.检查:舌右侧缘有几处糜烂和模糊的网状纹.两侧颊粘膜有放射纹状的白色线型损害.未作活检,临床诊断为扁平苔藓,采用局部类固醇治疗.6个月后舌部损害变成溃疡,活检的组织学改变表现为念珠菌侵入性粘膜白斑而不是扁平苔藓继发念珠菌感染.活 This article reports two cases of oral white lesions clinically diagnosed as lichen planus, given conservative treatment .A year rash morphological changes, the biopsy diagnosed as Candida leukoplakia, and then were in the original site of rash squamous cell carcinoma Case 1: Woman, 35 years old, complains of blisters on buccal mucosa for 5 months and swollen tongue for one month Previously healthy and without any skin problems She smoked only 3 or 4 cigarettes per day and occasional alcohol. The right side of the edge of several erosion and fuzzy mesh pattern on both sides of the buccal mucosa with radial pattern of white line damage.No biopsies, clinical diagnosis of lichen planus, the use of topical steroids treatment.6 months after the tongue damage Become ulcers, histological changes in biopsy showed candidal invasive leukoplakia instead of lichen planus secondary to Candida infection