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目的：探讨上皮性卵巢癌中血管内皮生长因子（ＶＥＧＦ）的表达及意义．方法：以ＳＡＢＣ免疫组化方法检测了３７例上皮性卵巢癌中ＶＥＧＦ表达．结果：上皮性卵巢癌、交界性卵巢肿瘤及良性肿瘤中ＶＥＧＦ表达率分别为７２．９７％，７５．０％及３８．４６％，恶性肿瘤及交界性肿瘤中ＶＥＧＦ表达率较良性肿瘤明显增高（Ｐ＜０．０５），且前两者的ＶＥＧＦ强阳性表达率也较良性肿瘤明显增高（Ｐ＜０．０５）．上皮性卵巢癌中ＶＥＧＦ表达率与淋巴结转移密切相关（Ｐ＜０．０５）．恶性肿瘤不同病理分级及临床分期ＶＥＧＦ表达率无明显差异（Ｐ＞０．０５）．结论：ＶＥＧＦ在与上皮性卵巢癌有关的血管形成中可能起着重要作用．
Objective: To investigate the expression and significance of vascular endothelial growth factor (VEGF) in epithelial ovarian cancer. Methods: The expression of VEGF in 37 cases of epithelial ovarian cancer was detected by SABC immunohistochemistry. Results: The positive rates of VEGF expression in epithelial ovarian cancer, borderline ovarian tumor and benign tumor were 72.97%, 75.0% and 38.46% respectively. The expression of VEGF in malignant and borderline tumors was significantly higher than that in benign tumors (P <0.05), and the strong expression of VEGF in the first two groups was also significantly higher than that in benign tumors (P <0.05). The expression of VEGF in epithelial ovarian cancer is closely related to lymph node metastasis (P <0.05). There was no significant difference in the expression of VEGF between different pathological grades and clinical stages of malignant tumors (P> 0.05). Conclusion: VEGF may play an important role in angiogenesis associated with epithelial ovarian cancer.