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脑膜炎奈瑟菌有好几种策略来逃逸补体介导的杀死作用,而这些使其有能力引起败血症和脑膜炎。这种脑膜炎球菌主要是人咽喉部的专性共栖菌,但它为什么进化了精巧的机制来逃逸宿主的免疫力尚不清楚。此文作者阐述了脑膜炎球菌免疫逃逸和对环境温度升高引起的补体增多发生抵抗的机制。作者在荚膜生物合成、H因子结合蛋白表达和脂多糖唾液酸化所需基因的5’非翻译区,鉴定了3个独立的RNA热传感物,它们是脑膜炎球菌抗免疫杀死必需的成分。因而升高的温度(发生在炎症期间)成
There are several strategies for N. meningitidis to escape complement-mediated killing, which have made it capable of causing sepsis and meningitis. This meningococcal species is primarily a obligate collectic fungus in the human throat, but it is unclear why it evolved a sophisticated mechanism to escape the host’s immunity. The authors describe mechanisms of meningococcal immune escape and resistance to increased complement caused by elevated ambient temperatures. The authors identified three independent RNA heat sensors in the 5 ’untranslated region of genes required for capsular biosynthesis, factor H binding protein expression and lipopolysaccharide sialylation, which are essential for anti-idiotypic meningococcal killing ingredient. Thus elevated temperature (occurring during inflammation)