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目的分析本院住院患者注射用质子泵抑制剂(PPI)使用情况。方法随机选取湖南中医药大学第二附属医院2016年11月各病室使用注射用PPI病历500份。汇总分析500份病历来源科室,患者性别、年龄、适应证,药物使用剂量、溶媒、用药频次、给药途径、疗程、重复用药等,以药品说明书、《湖南省质子泵抑制剂临床应用指导原则(试行)》(2016版)、《应激性溃疡防治专家建议》(2015版)等相关规定为依据,对本院注射用PPI(奥美拉唑、泮托拉唑和兰索拉唑)使用合理性进行评价。结果 500例患者中不合理使用注射用PPI 149例,占29.80%。其中骨伤科占比最高,为30.87%,其次是肛肠科。预防用药不合理占64.43%(96/149);治疗用药不合理占35.57%(53/149)。不合理用药主要集中在超适应证和超疗程使用,其中超适应证用药占62.42%,超疗程用药占32.89%。结论本院住院患者注射用PPI存在不合理现象,尤其是预防应激性溃疡用药,医院、医生及临床药师应共同努力,提高本院注射用PPI的临床用药合理性。
Objective To analyze the use of proton pump inhibitor (PPI) for inpatients in our hospital. Methods Randomly selected the Second Affiliated Hospital of Hunan University of Traditional Chinese Medicine in November 2016, the wards used 500 cases of PPI for injection. A total of 500 medical records source departments, patient sex, age, indications, drug dosage, vehicle, medication frequency, route of administration, course of treatment, repeated medication, etc. Drug instructions, "Guidelines for the clinical application of proton pump inhibitors in Hunan Province (Trial version) (2016 version) and Recommended Practice for Prevention and Treatment of Stress Ulcer (2015 version) and other related regulations, the PPI (omeprazole, pantoprazole and lansoprazole) Use the rationality to evaluate. Results 500 cases of unreasonable use of injection PPI 149 cases, accounting for 29.80%. Including orthopedic trauma accounted for the highest proportion of 30.87%, followed by anorectal. The unreasonable use of prophylaxis accounted for 64.43% (96/149); unreasonable treatment medication accounted for 35.57% (53/149). Irrational use of drugs mainly in the super-indications and ultra-treatment use, which accounted for 62.42% of the super-indications, medication over the course of 32.89%. Conclusion Inpatient inpatient injection of PPI there is an unreasonable phenomenon, especially in the prevention of stress ulcer medication, hospitals, doctors and clinical pharmacists should work together to improve our hospital injection of PPI clinical medication rationality.