目的:探讨小剂量多巴胺联合多巴酚丁胺辅助治疗小儿重症肺炎的临床效果及安全性。方法:选取重症肺炎患儿90例,随机分为2组。对照组行常规治疗,观察组在常规基础上辅以小剂量多巴胺联合多巴酚丁胺注射液治疗。比较两组患儿症状及生命体征改善情况、临床疗效和不良反应发生率。结果:观察组症状及生命体征改善的平均时间显著低于对照组,差异有统计学意义(P<0.01);观察组总有效率为95.56%明显高于对照组的82.23%,差异有统计学意义(P<0.05);比较两组不良反应发生率,差异无统计学意义(P>0.05)。结论:小剂量多巴胺联合多巴酚丁胺辅助治疗小儿重症肺炎疗效显著,安全性高。 Objective: To investigate the clinical efficacy and safety of low-dose dopamine combined with dobutamine in the treatment of pediatric severe pneumonia. Methods: Ninety children with severe pneumonia were selected and randomly divided into two groups. Control group routine treatment, the observation group supplemented with routine low-dose dopamine and dobutamine injection. The improvement of symptoms and vital signs, the clinical efficacy and the incidence of adverse reactions in both groups were compared. Results: The average time for improvement of symptoms and vital signs in observation group was significantly lower than that in control group (P <0.01). The total effective rate in observation group was 95.56%, which was significantly higher than that in control group (82.23%), the difference was statistically significant (P <0.05). There was no significant difference in the incidence of adverse reactions between the two groups (P> 0.05). Conclusion: Small dose of dopamine combined with dobutamine for the treatment of severe pneumonia in children is effective and safe.