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目的通过过敏性紫癜(HSP)患儿的血清IL-2、IL-6、IL-12探讨过敏性紫癜(HSP)的免疫作用机制。方法采用双抗夹心酶联免疫吸附试验(ELISA)法对48例HSP患儿组和48例正常组比较。结果 HSP患儿急性期的血清IL-6明显高于正常组(t=3.68 P<0.01),血清IL-2、IL-12则显著下降(分别为t=4.976 P<0.01,t=3.175 P<0.01)两组比较,差异有统计学意义。而HSP患儿恢复期的血清IL-2、IL-6、IL-12与正常组无明显差别(t=分别为0.703,0.374,0.490 P>0.05)两组比较,差异无统计学意义。结论 HSP患儿血清白细胞介素水平出现异常,机体存在免疫功能紊乱。
Objective To investigate the immunological mechanism of Henoch-Schonlein Purpura (HSP) by using serum IL-2, IL-6 and IL-12 in children with Henoch-Schonlein Purpura (HSP). Methods 48 cases of HSP group and 48 cases of normal group were compared by double-antibody sandwich enzyme-linked immunosorbent assay (ELISA). Results Serum levels of IL-6 in acute stage of HSP were significantly higher than those in normal group (t = 3.68 P <0.01), and serum IL-2 and IL-12 levels were significantly decreased (t = 4.976 P <0.01, t = 3.175 P <0.01) between the two groups, the difference was statistically significant. However, there was no significant difference between the two groups in serum IL-2, IL-6 and IL-12 in convalescent children with HSP (t = 0.703,0.374,0.490, P> 0.05). Conclusions Serum interleukin levels in children with HSP are abnormal, and the body has immune dysfunction.