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用氯化钙法和三氯化铁显色法对34例胃癌,41例食管癌的血清、癌组织中低密度脂蛋白(LDL)和胆固醇(CH)的含量进行了测定,并分别以50例慢性单纯性胃炎及20例正常食管的血清、胃窦组织和食管粘膜中LDL及CH含量为对照。结果表明癌症患者血清及癌组织中LDL和CH含量明显升高(P<0.05)。胃癌组织中LDL、CH含量低分化腺癌明显高于高分化腺癌(P<0.001)。结果揭示胃癌、食管癌细胞LDL代谢增强,血清LDL和CH可用于肿瘤的筛选及预后的判断;癌组织中LDL和CH含量的测定可作为胃腺癌分化分级的客观指标。
The serum levels of low-density lipoprotein (LDL) and cholesterol (CH) in 34 cases of gastric cancer, 41 cases of esophageal cancer, and cancer tissues were determined by the calcium chloride method and ferric chloride coloration method, Cases of chronic simple gastritis and 20 cases of normal esophageal serum, gastric antrum tissue and esophageal mucosal LDL and CH content were the controls. The results showed that LDL and CH levels in serum and cancer tissues of cancer patients were significantly higher (P<0.05). LDL and CH levels in poorly differentiated adenocarcinoma were significantly higher in gastric cancer than in well-differentiated adenocarcinoma (P<0.001). The results revealed that the metabolism of LDL in gastric cancer and esophageal cancer cells was enhanced. Serum LDL and CH could be used for the screening of tumors and the judgment of prognosis. The determination of LDL and CH in cancer tissues could be used as an objective index for the differentiation and classification of gastric adenocarcinoma.