论文部分内容阅读
目的探讨抗生素对癌症患者细菌感染,其合理使用的重要性。方法对278例接受各种治疗(包括抗生素)的癌症患者进行痰培养、细菌鉴定、药敏试验。结果223例患者检出条件致病菌,共294株,检出率为80.2%(223/278),革兰氏阴性菌为1607%(49/294),革兰氏阳性菌为11.9%(35/294),念珠菌为16.7%(49/294),卡它布兰汉菌为54.8%(161/294);混合感染占40.4%(90/223);革兰氏阴性杆菌及革兰氏阳性球菌对抗生素有较高和较广的耐药性,易形成新突变的耐药菌株。结论机体定植抵抗力与抗生素关系密切。合理使用抗生素可减少条件致病菌和多耐药性;反之,则可严重影响癌症患者生存质量。
Objective To investigate the importance of antibiotics in the bacterial infections of cancer patients and their rational use. Methods A total of 278 cancer patients undergoing various treatments, including antibiotics, were tested for sputum culture, bacterial identification and susceptibility. Results A total of 294 pathogenic bacteria were detected in 223 patients, with a detection rate of 80.2% (223/278), 1607% (49/294) for Gram-negative bacteria and 11.9% for Gram-positive bacteria 35/294), 16.7% (49/294) of Candida, 54.8% (161/294) of Brachyspira and 40.4% (90/223) of mixed infections. Gram-negative bacilli and Gram Cocci positive antibiotics have higher and broader resistance, easy to form new mutations in the resistant strains. Conclusion The body colonization resistance and antibiotics are closely related. Proper use of antibiotics can reduce the conditions of pathogens and multi-drug resistance; the other hand, it can seriously affect the quality of life of cancer patients.