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为了减少选择性5-HT重吸收抑制药(SSRI)的副作用,探讨了柴胡加龙骨牡蛎汤对埋球试验(MBT)的影响。 方法:实验动物为6周龄ddY系雄性小鼠,于恒温恒湿、12h明暗交替的环境下饲养,自由摄食及饮水。将1日量的柴胡加龙骨牡蛎汤中的生药用600ml水煎至半量,趁热过滤,冷冻干燥得提取物。试验时受试药(用水溶解)及阳性对照药均为经口给药,对照组只给予水。按照Njunge等的方法进行MBT。为了探讨受试药物对
In order to reduce the side effects of selective 5-HT reuptake inhibitors (SSRIs), the effect of Chaihujiao oyster soup on MBT was investigated. METHODS: The experimental animals were 6-week-old ddY male mice. They were raised in a constant temperature, humidity, and light and dark environment for 12 hours. They were fed and fed freely. The crude drug in the one-day amount of Bupleurum chinense oyster soup was immersed in half volume with 600 ml water, filtered while hot, and the extract was freeze-dried. Both the test drug (dissolved in water) and the positive control drug were administered orally during the test, and only water was administered to the control group. MBT is performed according to the method of Njunge et al. To explore the drug test