药物通过生物转化(以下简称生转),可被机体灭活或激活;因此代谢物(m)与母药一样,其体内动力学也将影响药物的疗效与毒性。若m具有显著的药理作用,则临床治疗必须考虑其药代动力学(PK)。导眠能过量中毒引起的昏迷过程,与母药血浓度(C)并不一致,却与代谢物的血浓度[C_(m)](以下凡是m的数据及参数,都以(m)注明)密切相关。有时m药理作用的临床意义,主要决定于它的PK特性。甲磺丁脲及醋磺环己脲(acetohexamide)都是降血糖药, The drug can be inactivated or activated by the body through biotransformation (hereinafter referred to as sporulation); therefore, the metabolite (m), like the parent drug, will have an effect on the pharmacokinetics and toxicity of the drug in vivo. If m has a significant pharmacological effect, clinical treatment must consider its pharmacokinetics (PK). Insomnia caused by excessive sleep poisoning process, and the concentration of the mother drug (C) is not consistent, but with the blood concentration of metabolites [C_ (m)] (The following are all m data and parameters are (m) indicate )closely related. Sometimes the clinical significance of m pharmacological effects, mainly depends on its PK characteristics. Metformin and acetohexamide are hypoglycemic agents,