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目的探讨低分子肝素治疗肾病综合征的疗效。方法选取2010年1月-2011年12月期间我科收治的肾病综合症患者96例作为研究对象,随机分为2组,观察组接受常规标准治疗以及低分子肝素;对照组仅接受常规标准治疗;所有患者均接受至少8W的治疗。比较两组患者的疗效。结果①观察组24h尿蛋白总量、血清尿素氮、血清肌酐治疗前后的降低幅度显著大于对照组,血清白蛋白治疗前后的升高幅度显著大于对照组,两组比较差异有统计学意义(P<0.05)。②观察组与对照组的不良反应发生率差异无统计学意义(P>0.05)。结论低分子肝素可提高常规标准方法治疗肾病综合征的疗效。
Objective To investigate the effect of low molecular weight heparin on nephrotic syndrome. Methods A total of 96 nephrotic syndrome patients admitted to our department from January 2010 to December 2011 were selected and randomly divided into two groups. The observation group received routine standard therapy and low molecular weight heparin. The control group received routine standard therapy All patients received at least 8W of treatment. Compare the efficacy of two groups of patients. Results ① The total amount of urinary protein, serum urea nitrogen and serum creatinine in observation group before and after treatment were significantly lower than those in control group. The increase of serum albumin before and after treatment was significantly higher than that of control group (P <0.05). ② There was no significant difference in the incidence of adverse reactions between the observation group and the control group (P> 0.05). Conclusion Low molecular weight heparin can improve the efficacy of routine standard treatment of nephrotic syndrome.