作者对矽肺患者和正常人的肺中胶原及粘多糖类进行了研究,并据此以探求矽肺组织纤维化的机理。从组织切片染色的结果证明矽肺比正常肺胶原纤维增多。将肺组织放在液氮中粉碎,用常规方法提取,分离和精制可溶性胶原。不溶性胶原用 GNBr 处理,得到 GNBr 肽,经过羧甲基纤维素及琼脂糖 A 1.5 m 柱层析, The authors studied collagen and mucopolysaccharidosis in the lungs of patients with silicosis and normal controls, and explored the mechanism of silicosis in silicosis. Staining from histological sections showed that silicosis increased compared to normal lung collagen fibers. Pulmonary tissue was pulverized in liquid nitrogen and the soluble collagen was isolated, purified and purified by conventional methods. Insoluble collagen was treated with GNBr to obtain GNBr peptide, which was subjected to 1.5 m column chromatography with carboxymethylcellulose and agarose,