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目的:探讨宫颈癌患者术后的生存情况及相关影响因素。方法:选取2006年1月至2010年12月182例宫颈癌患者为研究对象,对患者预后及其影响因素进行回顾性分析。使用Excel 2010软件与SPSS17.0统计软件对数据进行整理分析。结果:182例患者在接受治疗后1~5年累计生存率分别为98%、90%、82%、73%、63%。多因素Cox回归显示年龄、临床分期、淋巴结转移、癌栓形成是患者生存时间的独立影响因素。在控制了其他影响因素的情况下,相对于<40岁的患者,≥40岁的患者死亡相对危险度为1.627(95%CI为1.425~1.978);相对于Ⅰ期患者,Ⅱ期、Ⅲ~Ⅳ期患者死亡相对危险度分别为1.237(95%CI为1.089~1.523)、2.408(95%CI为2.125~2.873);相对于有淋巴结转移的患者,无淋巴结转移的患者相对危险度为0.374(95%CI为0.203~0.545);相对于治疗过程中未合并癌栓的患者,合并癌栓的患者死亡相对危险度为1.931(95%CI为1.532~2.339)。结论:加强肿瘤筛检、加大对高龄患者关注是改善宫颈癌患者预后的重要措施。
Objective: To investigate the postoperative survival of cervical cancer patients and related factors. Methods: A total of 182 patients with cervical cancer from January 2006 to December 2010 were selected as the study subjects. The prognosis and influencing factors were retrospectively analyzed. Use Excel 2010 software and SPSS17.0 statistical software to organize the data analysis. Results: The cumulative survival rates of 182 patients 1 year to 5 years after treatment were 98%, 90%, 82%, 73% and 63%, respectively. Multivariate Cox regression analysis showed that age, clinical stage, lymph node metastasis and thrombus formation were independent influencing factors of survival time. The relative risk of death in patients ≥40 years of age was 1.627 (95% CI, 1.425 to 1.978) relative to those in patients with stage I, relative to controls younger than 40 years, The relative risk of death in stage Ⅳ patients was 1.237 (95% CI 1.089-1.523) and 2.408 (95% CI 2.125-2.873) respectively. The relative risk of death without lymph node metastasis was 0.374 95% CI: 0.203-0.545). The relative risk of death from patients with tumor thrombus was 1.931 (95% CI 1.532 to 2.339) relative to patients without thrombus during the course of treatment. Conclusion: It is an important measure to improve the prognosis of patients with cervical cancer by strengthening cancer screening and increasing attention to elderly patients.