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目的:探讨TLT-plus液基细胞学检测系统在妇科普查中的价值。方法:分析该院2006年12月～2009年6月11 030例宫颈液基细胞学检查结果,所有病例均采用宁波美生医疗器材有限公司的液基细胞学产品(TLT-plus液基细胞学检测系统)制片,用TBS系统报告方式。对其中711例阳性病人进行组织学活检,对比分析宫颈细胞学和组织学检查结果。结果:11 030例液基细胞学检查结果中无明确诊断意义的非典型鳞状上皮细胞(ASC-US)以上病例为757例,阳性检出率为6.86%。在711例细胞学阳性和组织学活检结果的对比中,165例低度鳞状上皮内病变(LSIL)中湿疣和宫颈上皮内瘤变(CINI)为96例,符合率58.18%,过诊断(炎症)43例,占26.06%,低诊断(CINII和CINIII)26例,占15.76%。49例高度鳞状上皮内病变(HSIL)中CINII、CINIII共25例,符合率为51.02%,过诊断23例,占45.10%(炎症3例,湿疣2例,CINI 18例),低诊断仅1例(鳞癌)。ASC-US、高级别非典型鳞状细胞(ASC-H)、非典型腺细胞无其他特殊意义(AGC-NOS)共497例,其中检出湿疣和CIN 114例,检出率为22.94%。结论:TLT-plus液基细胞学检测系统是一种有效的宫颈癌前病变筛查方法,TLT-plus液基细胞学检测系统对宫颈癌前病变的检查存在假阴性和假阳性,对细胞学检查异常的病例应活检进一步确认。
Objective: To investigate the value of TLT-plus liquid-based cytology detection system in gynecological survey. Methods: The results of 1130 cervical cytology tests from December 2006 to June 2009 were analyzed. All cases were treated with liquid-based cytology (TLT-plus liquid-based cytology Detection System) Production, using the TBS system to report. Of these 711 positive patients were histologically biopsied, and cervical cytology and histological findings were compared. Results: There were 757 cases of atypical squamous cell (ASC-US) in 11 030 liquid-based cytology without definite diagnosis, the positive rate was 6.86%. In a comparison of 711 cytological positive and histological biopsy results, 96 cases of LSCC with condyloma acuminatum and cervical intraepithelial neoplasia (CINI) were found in 96 cases, with a coincidence rate of 58.18% Inflammatory) 43 cases, accounting for 26.06%, low diagnosis (CINII and CINIII) 26 cases, accounting for 15.76%. Among 49 cases of high grade squamous intraepithelial lesion (HSIL), 25 cases were CINII and CINIII, with a coincidence rate of 51.02%, 23 cases (45.3%), 3 cases of inflammation, 2 cases of genital warts and 18 cases of CINI. 1 case (squamous cell carcinoma). There were 497 cases of ASC-US, ASC-H, AGC-NOS without any special significance (AGC-NOS), of which 114 cases were detected with genital warts and CIN. The detection rate was 22.94%. Conclusion: TLT-plus liquid-based cytology detection system is an effective screening method of cervical precancerous lesions, TLT-plus liquid-based cytology detection system for cervical precancerous lesions there is a false negative and false positive, cytological Abnormal examination of the biopsy should be further confirmed.