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目的观察纳洛酮联合高压氧综合疗法治疗急性一氧化碳中毒的临床疗效。方法我科于2008年11月至2010年2月共收治97例急性一氧化碳中毒患者,随机分为对照组48例和观察组49例。两组患者均给予常规的对症支持治疗,对照组给予高压氧治疗,观察组在对照组的基础上给予纳洛酮,观察两组的临床疗效。结果观察组的总有效率为95.9%,对照组的总有效率为68.8%,两组比较差异有统计学意义(P<0.05);观察组的平均昏迷时间和迟发性脑病及病死率与对照组比较差异亦有统计学意义(P<0.05)。结论纳洛酮联合高压氧综合疗法治疗急性一氧化碳中毒疗效显著,能明显缩短患者昏迷时间,减少迟发性脑病的发生率及病死率,值得推广应用,
Objective To observe the clinical efficacy of naloxone combined with hyperbaric oxygen therapy in the treatment of acute carbon monoxide poisoning. Methods A total of 97 patients with acute carbon monoxide poisoning were admitted to our department from November 2008 to February 2010 and were randomly divided into control group (48 cases) and observation group (49 cases). Two groups of patients were given conventional symptomatic and supportive treatment, the control group was given hyperbaric oxygen therapy, the observation group was given naloxone on the basis of the control group, and the clinical efficacy was observed. Results The total effective rate was 95.9% in the observation group and 68.8% in the control group, with significant difference between the two groups (P <0.05). The average coma time, delayed encephalopathy and mortality in the observation group were The difference between the control group was also statistically significant (P <0.05). Conclusion Naloxone combined with hyperbaric oxygen therapy in the treatment of acute carbon monoxide poisoning significant effect, can significantly shorten the coma time and reduce the incidence of delayed encephalopathy and mortality, it is worth promoting the application,