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为了优选恩诺沙星淀粉微球的最佳制备工艺,试验将反相乳液聚合法与包埋载药法结合起来,以可溶性淀粉为载体、环氧氯丙烷为交联剂,制备恩诺沙星淀粉微球;以载药量和包封率为指标,通过L9(34)正交试验对制备工艺进行优化,采用扫描电镜观察载药微球的粒径大小及形态。结果表明:最佳工艺条件为淀粉4 g、恩诺沙星0.04 g、交联剂1.0 g、乳化剂0.8 g、反应时间2 h;按照此优化工艺参数制得的载药微球的总载药量为2.53%、包封率为89.72%;恩诺沙星淀粉微球大小较均匀,形态圆整,分散性较好,粒径为60μm左右;在最初2.5小时时释药量约为43.12%,至第8小时时释药量达80.69%,之后逐步释放,到第10小时时累积释药量占总药量的82.51%。说明此制备工艺可行,所制得的恩诺沙星淀粉微球具有一定的缓释效果。
In order to optimize the preparation process of enrofloxacin starch microspheres, the reverse phase emulsion polymerization method and embedding drug loading method combined with soluble starch as carrier, epichlorohydrin as crosslinking agent, preparation of enoxaparin Starched starch microspheres. The drug loading and entrapment efficiency were used as indexes to optimize the preparation process by L9 (34) orthogonal test. The size and morphology of drug-loaded microspheres were observed by scanning electron microscopy. The results showed that the optimum conditions were starch 4 g, enrofloxacin 0.04 g, crosslinker 1.0 g, emulsifier 0.8 g and reaction time 2 h. The total loading of drug-loaded microspheres The dose of enrofloxacin starch microspheres was more uniform, the morphology was better, the dispersibility was better, the particle size was about 60μm, and the encapsulation efficiency was 89.72%. The dosage of enrofloxacin at the first 2.5 hours was about 43.12 %, To the eighth hour when the release rate of 80.69%, and then gradually release, to the first 10 hours when the cumulative release of the total dose of 82.51%. This shows that the preparation process is feasible, and the prepared enrofloxacin starch microspheres have a certain sustained release effect.