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动脉硬化性闭塞症(ASO)是临床常见的周围血管疾病之一,其发病率和病死率的逐年升高,引起了临床工作者的广泛关注和重视。动物模型的制备是ASO病因学与治疗研究的前提。目前,现代医学范畴的ASO动物模型包括高脂模型、内膜损伤模型、血管结扎模型等,而成熟的中医证候ASO模型较少,现有的动物模型多源自“脱疽”、“脉痹”研究的病理模型。本文对ASO模型的中西医研究现状作一综述。
Arteriosclerotic occlusive disease (ASO) is one of the most common peripheral vascular disease in clinic. The increasing incidence and mortality of ASO have aroused widespread concern and attention of clinicians. The preparation of animal models is a prerequisite for the study of etiology and treatment of ASO. At present, ASO animal models in the field of modern medicine include the high fat model, the intimal injury model, the vascular ligation model and the like, while the mature TCM syndrome ASO models are few. The existing animal models are mostly derived from “ ”Pulse paralysis " pathological model of the study. This article reviews the status quo of Chinese and Western medicine research on ASO model.