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对5种五味子属(Schisandra)药用植物(小花五味子Schisandra micrantha,狭叶五味子S. lancifolia,滇翼梗五味子S. henryi var. yunnanensis var.yunnanensis,复瓣黄龙藤S. Plena,华中五味子S. sphenanthera)和唇形科植物东紫苏(Elsholtzia bodinieri)的化学成分进行了研究,从中共分离鉴定了101个化合物,26个为新化合物.首次从3种五味子属植物中发现了3种高度氧化的新奇骨架类型.此外,还发现了18,19-seco-乌索酸型苷和17,20断裂并失去17位侧链的羊毛甾烷型和环阿尔廷型八降三萜等新的骨架类型.对分离得到的部分化合物进行了体外抗HIV-1、急毒、抗炎和抗肿瘤活性实验,发现部分化合物具有抗HIV-1活性.其中化合物SM-10和SM-26具有显著的抑制HIV-1病毒活性,选择指数分别为174.08和>25.04,且毒性较小,作为作用于病毒与细胞结合和融合靶点的小分子化合物具有重要的意义.
Five Schisandra medicinal plants (Schisandra micrantha, S. lancifolia, S. henryi var. yunnanensis var. yunnanensis, S. Plena, S. Plena, S. sphenanthera The chemical constituents of sphenanthera) and the lablab plant (Elsholtzia bodinieri) were studied. 101 compounds were identified from the Chinese Communist Party, 26 of which were new compounds. For the first time, three highly oxidized species were discovered from the three Schisandra species. The novelty skeleton type. In addition, 18,19-seco-ursenoic glycosides and new skeletons such as lanostane type and cycloartenolone triterpenoids that break and lose the 17-position side chain have also been found. Type. In vitro anti-HIV-1, acute toxicity, anti-inflammatory and anti-tumor activities were tested on some of the isolated compounds. Some compounds were found to have anti-HIV-1 activity. Among them, compounds SM-10 and SM-26 have significant inhibition. HIV-1 virus activity, selection index was 174.08 and >25.04, respectively, and toxicity was small. It has important significance as a small molecule compound that acts on the target of virus and cell binding and fusion.