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大量观察结果表明前列腺素E和I及其人工合成同类物可保护胃、十二指肠粘膜免受损害。作者曾以内镜检查证实,恩前列素(enprostil)可减轻阿斯匹林短期使用引起的胃、十二指肠粘膜损害。本文对恩前列素防止酒精诱发人胃粘膜损害的效果进行了研究。材料与方法:对8名成年健康男性作随机、双盲、自身安慰剂对照试验。两次检查间隔一周。当内镜检查证实食管、胃、十二指肠粘膜正常后,吸尽胃液,通过导管喷入10ml试验液至幽门前胃窦粘膜(对照组为1 ml丙烯碳酸盐溶液,试验组为1 ml恩前列素丙烯碳酸盐溶液,各加水至10 ml)。镜下观察15分钟后,将胃窦粘
A large number of observations show that prostaglandin E and I and their synthetic congeners can protect the stomach and duodenal mucosa from damage. The authors have confirmed by endoscopy, enprostyl (enprostil) can reduce the short-term use of aspirin stomach and duodenal mucosal damage. In this paper, the effect of enprost to prevent alcohol-induced human gastric mucosal damage were studied. Materials and Methods: Eight adult healthy men were randomized, double-blind, placebo-controlled trials. Two inspections a week apart. When the esophagus, stomach and duodenal mucosa were confirmed to be normal by endoscopy, the gastric juice was aspirated and 10 ml of the test solution was injected through the catheter to the anterior pylorus antral mucosa (1 ml propylene carbonate solution in the control group, the test group was 1 ml enrapropion propylene carbonate solution, each water up to 10 ml). Microscope observed after 15 minutes, the gastric antrum sticky