论文部分内容阅读
目的观察胃铋镁四联疗法对柯尔克孜族慢性胃炎患者治疗的效果。方法选择2015年12月~2016年11月克孜勒苏柯尔克孜自治州人民医院收治的柯尔克孜族Hp相关慢性胃炎患者160例,随机分为治疗组和对照组,每组80例。治疗组口服胃铋镁颗粒+奥美拉唑+阿莫西林+克拉霉素14 d,对照组口服胶体果胶铋+奥美拉唑+阿莫西林+克拉霉素14 d,两组患者再增加服用铋剂14 d。比较Hp根除、上腹痛缓解及不良反应发生情况。结果治疗组Hp根除率为91.2%,略优于对照组的81.2%,差异无统计学意义(P>0.05)。治疗组上腹痛症状缓解率为100.0%,显著优于对照组的92.5%,差异有统计学意义(P<0.05)。治疗组不良反应发生率为5.0%,显著低于对照组的18.8%,差异有统计学意义(P<0.01)。结论胃铋镁四联疗法在临床上对柯尔克孜族慢性胃炎患者Hp根除效果显著,对上腹痛症状缓解效果优于胶体果胶铋四联疗法,同时减少了不良反应发生,值得在少数民族地区推广。
Objective To observe the effect of gastric bismuth and magnesium quadruple therapy in the treatment of Kirgiz chronic gastritis patients. Methods A total of 160 Hp-related chronic gastritis patients from the Kirgiz Autonomous Prefecture People’s Hospital of Kyrgyz Republic from December 2015 to November 2016 were randomly divided into treatment group (n = 80) and control group (n = 80). The treatment group was treated with gastric bismuth magnesium granules + omeprazole + amoxicillin + clarithromycin for 14 days, while the control group was treated with colloidal bismuth pectin + omeprazole + amoxicillin + clarithromycin for 14 d Increase the use of bismuth 14 d. Hp eradication, abdominal pain relief and adverse reactions occurred. Results In the treatment group, the eradication rate of Hp was 91.2%, slightly better than that of the control group (81.2%). There was no significant difference (P> 0.05). The remission rate of the symptoms of upper abdominal pain in the treatment group was 100.0%, which was significantly better than that of the control group (92.5%), the difference was statistically significant (P <0.05). The incidence of adverse reactions in the treatment group was 5.0%, which was significantly lower than that in the control group (18.8%), the difference was statistically significant (P <0.01). Conclusions Stomach bismuth magnesium quadruple therapy has a significant clinical effect on Hp eradication in patients with chronic gastritis in the Kirgiz population and is superior to colloidal pectin bismuth quadruple therapy in relieving symptoms of upper abdominal pain and at the same time it reduces adverse reactions and is worth promoting in ethnic minority areas .