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目的检测多环芳烃暴露人群诱发电位的变化情况。方法按炉顶、炉侧、炉底不同作业岗位各随机选取15名焦炉工为暴露组,另选一般情况相近的25名库工为对照组。高效液相色谱法检测研究对象尿中1-羟基芘水平;Neuropack M1肌电图仪进行体感诱发电位(SEP)、听觉诱发电位(AEP)和视觉诱发电位(VEP)的测定。结果尿中1-羟基芘对照组、炉底组、炉侧组、炉顶组分别为(2.71±0.22),(3.29±0.38),(3.63±0.55),(4.13±0.62)μmol/mol Cr,呈现炉顶>炉侧>炉底>对照的趋势;各组体感诱发电位、听觉诱发电位和视觉诱发电位各指标经方差分析,差异无统计学意义(P<0.05)。结论在目前的接触水平下,多环芳烃暴露人群躯体感觉传导通路、听觉传导通路和视觉传导通路未发生明显异常。
Objective To detect the changes of evoked potentials in people exposed to PAHs. Methods Fifteen coke oven workers were randomly selected as the exposure group according to the top of the stove, the side of the furnace and the bottom of the furnace, and 25 workers in similar situations were selected as the control group. The level of 1-hydroxypyrene in urine was detected by high performance liquid chromatography (HPLC). The somatosensory evoked potential (SEP), auditory evoked potential (AEP) and visual evoked potential (VEP) were measured with Neuropack M1 electromyograph. Results The urinary concentrations of 1-hydroxypyrene were 2.71 ± 0.22, 3.29 ± 0.38, 3.63 ± 0.55, 4.13 ± 0.62 μmol / mol Cr in the control, hearth, (P <0.05). There was no significant difference between each group of somatosensory evoked potentials, auditory evoked potentials and visual evoked potentials by variance analysis. Conclusions At the current level of exposure, no significant abnormalities were found in somatosensory conduction pathways, auditory conduction pathways and visual conduction pathways in PAH-exposed subjects.