论文部分内容阅读
小鼠径口投与用~(14)C标记的乌洛托品(放射性为12.6微居里/毫克),3~4小时内由尿中大约排出所使用~(14)C的76%,其中37%为未变化的乌洛托品,7%为在尿道中分解生成的甲醛,11%为与变色酸不起反应的另一种形式的挥发性化合物(可能是甲酸),21%为不挥发性,与酸作用也不游离出甲醛的物质。仅有2%可由呼气CO_2中检出。有5%在未被吸收前即已水解。在粪便与肠内容物中有2.5%。在22小时后体内仍残留
Approximately 76% of the 14C used in urine was excreted in the urine within 3 to 4 hours, with 37% of the urine (12.6 microgas / mg) % Is untreated urotropine, 7% formaldehyde formed by decomposition in the urethra, 11% is another form of volatile compound (possibly formic acid) that does not react with chromotropic acid, and 21% is non-volatile Sexual, with the role of acid nor free formaldehyde substances. Only 2% can be detected by expired CO2. 5% hydrolyzed before it was absorbed. 2.5% in feces and intestinal contents. The body remains after 22 hours