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目的探讨类风湿因子(RF)与抗环瓜氨酸肽抗体(抗CCP抗体)联合检测的临床应用价值。方法使用酶联免疫吸附法(ELISA 法)检测我院150例类风湿关节炎(RA)患者(A组)、28例非RA患者(B组)以及34例健康人群(C组)的血清，比较三组人群血清中RF、抗CCP抗体单独或联合使用对诊断RA的敏感性、特异性等。结果 A组人群抗CCP抗体和RF阳性率比B组、C组高(P<0.01)；A组中单独使用RF的敏感性高于抗CCP抗体，抗CCP抗体的特异性高于RF，联合使用抗CCP抗体和RF，其检测敏感性、阴性预测值及约登指数等高于抗CCP抗体或RF单独使用。结论抗CCP抗体和RF联合使用用于诊断RA具有良好的临床应用价值。“,”Objective To investigate the analysis of rheumatoid factor and anti-citrulline antibody combined detection for the clinical application value. Methods Using enzyme-linked immunosorbent assay(ELISA method) to our hospital for the treatment of 150 cases of rheumatoid arthritis(RA) patients(A group), 28 cases of non-RA patients(B group) and 34 cases of healthy people(C group) were detected in serum, compared three groups of serum rheumatoid factor, anti-citrulline antibody for use alone or in combination for the diagnosis of rheumatoid arthritis sensitivity, specificity and so on. Results A group of people for anti-citrulline antibodies and rheumatoid factor positive rate than the B group, C group high(P <0.01); A group of rheumatoid factor alone sensitive than anti-citrulline antibodies for the anti-citrulline antibody specificity for the above rheumatoid factor, combined use of anti-citrulline conversion and rheumatoid factor antibodies, the detection sensitivity and negative predictive values, and Youden index for other than anti-citrulline antibodies or rheumatoid factor when used alone. Conclusion Anti-changer citrulline antibody and rheumatoid factor used in combination for the diagnosis of rheumatoid arthritis with good clinical practice.