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目的:研究单侧输卵管切除术对体外受精-胚胎移植(IVF-ET)周期卵巢反应性和妊娠结局的影响。方法:以行IVF-ET单侧输卵管切除的106例不孕患者为研究组,同期双侧输卵管梗阻的患者360例为对照组,比较研究组输卵管切除后术侧和健侧超促排卵启动日卵巢的大小和窦卵泡数、hCG注射日卵巢的大小、≥12mm卵泡数和获卵数,同时比较研究组和对照组≥12mm卵泡数、获卵数、受精数、优质胚胎数以及Gn用量、用药天数、妊娠率。结果:研究组中术侧和健侧启动日卵巢的大小无显著性差异,然而超促排卵启动日窦卵泡数、hCG注射日双侧卵巢大小、≥12mm卵泡数和获卵数均有统计学差异。研究组无论是hCG注射日≥12mm卵泡数、获卵数、Gn用量、用药天数,还是受精数、优胚数和妊娠率与对照组比较,均无显著性差异。结论:单侧输卵管切除术降低同侧卵巢的反应性,但总体上不影响卵巢对Gn的反应和IVF-ET妊娠结局。
Objective: To investigate the effect of unilateral tubal resection on ovarian response and pregnancy outcome in IVF-ET. Methods: One hundred and sixty cases of infertility treated with IVF-ET unilateral fallopian tube were selected as the study group. 360 patients with bilateral tubal obstruction during the same period were selected as the control group. The initiating day Ovarian size and antral follicle count, ovarian size on hCG injection day, the number of follicles ≥12mm and the number of oocytes retrieved. At the same time, the number of follicles ≥12mm, the number of oocytes retrieved, the number of fertilization, the number of high quality embryos and Gn, Medication days, pregnancy rate. RESULTS: There was no significant difference in ovarian size between the start-up day and the contralateral start-up day in the study group, however, the number of primordial follicles initiated by superovulation, the ovarian size at day of hCG injection, the number of follicles ≥12 mm and the number of oocytes retrieved were all statistically difference. No significant difference was found in the number of follicles, the number of oocytes retrieved, the amount of Gn, the number of days of application, the number of fertilization, the number of excellent embryos and the pregnancy rate of the study group on the day of hCG injection. CONCLUSIONS: Unilateral tubal resection reduces ipsilateral ovarian reactivity, but generally does not affect ovarian response to Gn and IVF-ET pregnancy outcomes.