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目的探讨脑膜血管瘤病(MA)的临床病理学特点。方法观察1例MA患者的临床表现、MRI及组织学特点,并复习相关文献。结果患者女性,23岁。因发作性癫1年余入院。MRI示右顶叶皮质内约2.6 cm×2cm大小团片状短T2、长T1及等T1异常信号。镜检示脑膜上皮细胞和纤维母细胞样梭形细胞增生,并围绕在皮质内的小血管周围,伴有钙化和砂砾体形成,病灶内可见残存的神经元和胶质细胞。免疫组化显示增生的梭形细胞vimentin(+);血管内皮细胞CD34(+);残留的胶质细胞GFAP和Olig-2(+)。结论 MA为脑皮质良性病变,预后良好。形态学上MA需与侵袭性脑膜瘤、神经节细胞胶质瘤、动静脉血管畸形等鉴别。
Objective To investigate the clinicopathological features of meningioma (MA). Methods The clinical manifestations, MRI and histological features of 1 patient with MA were observed and the related literatures were reviewed. Results Female patient, 23 years old. Due to episodes of epilepsy more than 1 year admitted to hospital. MRI showed right parietal cortex about 2.6 cm × 2cm size of the small group of short T2, T1 and T1 and other abnormal signals. Microscopically, mesangial cells and fibroblast-like spindle cells proliferated and surrounded the small blood vessels in the cortex, with calcification and gravel formation, with remnants of neurons and glial cells visible in the lesion. Immunohistochemistry showed hyperplastic spindle cells vimentin (+); vascular endothelial cells CD34 (+); residual glial cells GFAP and Olig-2 (+). Conclusion MA is a benign cerebral cortex with a good prognosis. Morphological MA and invasive meningioma, ganglion cell glioma, arteriovenous malformations and other identification.