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以红紫素-18甲酯为原料,与脂肪胺或者苯胺在加热回流和微波促进的条件下进行胺解反应,分别得到单酰胺化、双酰胺化和羰基亚胺化产物;同时,沿着N21-N23轴向对所得红紫素-18酰亚胺实施化学修饰,分别得到难以分离的具有阻旋异构和差向异构特征的红紫素-18酰亚胺混合物.新的二氢卟吩类衍生物均经UV,IR,1H NMR光谱、质谱及元素分析证明其结构,并对相应的胺解反应提出了可能的反应机理.
The reaction was carried out with amidite-18 methyl ester as the raw material and amidation reaction with aliphatic amine or aniline under the conditions of refluxing and microwave heating to obtain monoamidated, diamidated and carbonylimidated products, respectively. At the same time, N21-N23 axial chemical modification of the obtained purpurin-18 imide, respectively, were difficult to isolate with a hindrance heteromeric and epimeric purpurin-18 imide mixture of new dihydro The porphyrin derivatives have been confirmed by UV, IR, 1H NMR spectra, mass spectra and elemental analysis, and the possible reaction mechanism was proposed for the corresponding aminolysis reaction.