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强直性脊柱炎(ankylosing spondylitis,AS)是一种自身免疫性疾病。由于AS以好发于青少年,以发病早、病程长、致残率高为主要特点,所以早期诊断及治疗,对改善AS患者的预后、提高其生活质量起着至关重要的作用。但目前除了人类白细胞抗原B27(HLA-B27)及影像学的改变外,还没有找到其他更特异和敏感的实验室指标用于AS的早期诊断。近几年来,随着人们对AS发病机制研究的进展,发现了某些细胞因子在AS发生、发展中起着重要作用。本文作者主要对CXCR4/SDF-1反应轴与VEGF与强直性脊柱炎的发生、发展和转归的关系以及是否可能成为AS靶向治疗的主要靶点的相关研究予以阐述。
Ankylosing spondylitis (AS) is an autoimmune disease. As AS is predominant in adolescents, with the characteristics of early onset, long course of disease and high morbidity, early diagnosis and treatment play an important role in improving the prognosis of AS patients and improving their quality of life. However, in addition to the human leukocyte antigen B27 (HLA-B27) and imaging changes, but no other more specific and sensitive laboratory indicators for the early diagnosis of AS. In recent years, with the progress of the research on the pathogenesis of AS, some cytokines have been found to play an important role in the occurrence and development of AS. The authors mainly describe the relationship between CXCR4 / SDF-1 axis and the occurrence, development and outcome of VEGF and ankylosing spondylitis, and the possibility of becoming the main target of AS-targeted therapy.