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预防接种是贯彻执行毛主席“预防为主”方针的重要措施。在流行病学工作中,应用生物制品防治传染病具有决定性的作用。随着免疫学的进展和生物制品的广泛应用,也需要对发现的新问题加以探讨。笔者在农村曾见到1例因接种白喉类毒素而发生慢性溃疡的儿童,局部溃疡延续两年半,并合并自身免疫病。此例患儿住院6年余,在病程中多次出现恶化和反复。在1965～1973年我们对其进行了较长时期的观察。鉴于本例极罕见,目前国内外文献中尚未见到,故予报道,以供免疫、临床和流行病学研究参考。
Vaccination is an important measure to implement Chairman Mao’s principle of “prevention first”. In epidemiological work, the application of biological products to prevent and control infectious diseases has a decisive role. With the progress of immunology and the wide application of biological products, new problems discovered also need to be explored. I have seen in rural areas one case of chronic ulcer due to diphtheria toxoid inoculation children, local ulcers for two and a half years, and merged with autoimmune diseases. This case of children hospitalized more than 6 years, many times in the course of deterioration and repeated. In 1965 ~ 1973 we conducted a longer period of observation. In view of this extremely rare cases, the current literature at home and abroad have not yet seen, it is reported for immunization, clinical and epidemiological studies for reference.