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目的 探讨心理干预对急性有机磷农药中毒患者的影响.方法 将2012年7月-2015年6月本院收治的80例口服有机磷农药中毒且神智清醒的患者随机分为心理干预组40例、对照组40例.2组均行洗胃、导泻、吸附、保肝护胃、适量应用长托宁及阿托品解毒,氯磷定复能剂等综合常规治疗,干预组在上述治疗的同时行心理干预.评估2组患者的焦虑、抑郁心理状态及对治疗的依从性.比较2组首次排便时间、胃肠功能恢复时间、阿托品化时间、胆碱酯酶(CHE)活力恢复50％以上时间、住院时间及阿托品、长托宁用量以及胃肠功能不全、药物耐受、中毒反跳、中间综合征发生率及病死率比较.结果 心理干预组的焦虑、抑郁评分均低于对照组,对治疗的依从性明显好于对照组(P ＜0.05,P＜0.01);心理干预组的首次排便时间、胃肠功能恢复时间、阿托品化时间、CHE活力恢复至50％以上时间,阿托品、长托宁用量以及胃肠功能不全、中毒反跳、中间综合征发生率均明显低于对照组(P ＜0.05,P＜0.01).结论 心理干预在治疗急性有机磷农药中毒的过程中有明显的干预作用,在综合治疗中不可或缺.“,”Objective To explore the therapeutic effect of psychological intervention on the prognosis of acute organophosphate poisoning.Methods 80 conscious patients with organophosphate poisoning were randomly divided into 2 groups:a psychological intervention group and control group,both groups will be treated with gastric lavage and catharsis,adsorption,protecting liver and stomach,the amount of application of penehyclidine hydrochloride and atropine detoxification,comprehensive routine treatment of chlorine and phosphorus compound.Otherwise,the intervention group was treated with psychological intervention.Lately,anxiety,depression,mental status and compliance to treatment were assessed.The first defecation time,gastrointestinal function recovery time,atropinization time,the time of cholinesterase (CHE) activity recovery to more than 50％,hospitalization time and dosage of atropine,penehyclidine hydrochloride and gastrointestinal dysfunction,drug resistance,poisoning rebound and intermediate syndrome incidence and mortality were compared between two groups.Results The anxiety and depression scores of psychological intervention group were lower than that of the control group,the patients of psychological intervention group showed significantly better compliance to treatment than the control group (P＜0.01 or P＜0.05).The psychological intervention group the first defecation time,gastrointestinal function recovery time,atropinization time,the time of cholinesterase (CHE) activity recovery to more than 50％;atropine,penehyclidine hydrochloride dosage and gastrointestinal dysfunction,poisoning rebound and intermediate syndrome incidence is significantly lower than that of control group (P＜ 0.01 or P＜0.05).Conclusion Psychological intervention have a significant benefit in the treatment of acute organiophosphate poisoning and it is necessary in the comprehensive treatment.