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本实验将小鼠可移植性网织细胞肉瘤ＬⅡ接种子近交系６１５小鼠体内进行自发转移特性的观察。实验分为两组，Ａ组将定量（１×１０）的ＬⅡ瘤细胞接种于小鼠右后肢肌肉内，Ｂ组将等量的瘤细胞接种于小鼠右肋部皮下，待荷瘤小鼠自然死亡或濒死状态时处死，取出全肺及各部位淋巴结进行组织学检查。结果发现２４只右后肢肌肉接种的动物，中间存活时间为２８天，全部实验动物均发生淋巴结和肺转移；２３只右肋皮下接种的动物，中间存活时间为３９天，有９５．７％（２２／２３只）发生淋巴结转移，６０．９％（１４／２３只）出现肺转移，而淋巴结合并肺转移者５６．５％（１３／２３只）。结果表明，本瘤株具有淋巴结合并肺部双向转移的特性。
In this experiment, the characteristics of spontaneous metastasis of mouse transplantable reticulocyte sarcoma LII vaccinia inbred 615 mice were observed. The experiments were divided into two groups. In group A, quantitative (1×10) LII tumor cells were inoculated into the muscles of the right hind limbs of mice. In group B, equal amounts of tumor cells were inoculated subcutaneously into the right flank of mice and were to be administered to tumor-bearing mice. In the state of natural death or sudden death, all lymph nodes were removed and histological examinations were performed. The results showed that 24 animals inoculated in the right hindlimb muscle had an intermediate survival time of 28 days. Lymph node and lung metastasis occurred in all experimental animals; 23 animals inoculated subcutaneously in the right ribs had an intermediate survival time of 39 days (95.7%). Twenty-two (23) developed lymph node metastases, 60.9% (14/23) developed lung metastases, and 56.5% (13/23) had lymphatic metastases and lung metastases. The results showed that this tumor strain has the characteristics of lymphatic binding and bidirectional lung metastasis.