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目的探讨大Y染色体对男性生育的影响以及临床意义。方法常规外周血淋巴细胞培养制备染色体标本,G显带核型分析928例检测者。结果检出异常核型124例,男性异常核型56例,大Y染色体携带者38例,大Y染色体的检出率为4.09%(38/928),占异常核型的30.65%(38/124),占男性异常核型的67.86%(38/56)。可导致其配偶发生习惯性流产、生育智力低下儿、长期不育、有死胎史、有畸形儿生育史以及新生儿死亡并流产等。结论大Y染色体与男性的生育有关,有一定的临床意义。
Objective To investigate the effect of large Y chromosome on male fertility and its clinical significance. Methods Chromosome samples were prepared by routine peripheral blood lymphocyte culture, and 928 cases of G-banding karyotype were detected. Results There were 124 cases of abnormal karyotype detected, 56 cases of male abnormal karyotype and 38 cases of large Y chromosome. The detection rate of large Y chromosome was 4.09% (38/928), accounting for 30.65% (38 / 124), accounting for 67.86% (38/56) of male abnormal karyotypes. Can lead to habitual abortion of their spouses, fertility mental retardation, long-term infertility, a history of stillbirth, history of deformed children and neonatal death and abortion. Conclusion Large Y chromosome is associated with male fertility and has certain clinical significance.