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作者报告且分折了15例Weber-christian病(WCD)患者,并与文献中报告的253例进行比较。临床特征:平均年龄42岁,12例女性,3例男性。两下肢皮下结节(92%),或两上肢皮下结节(60%),发热(80%),关节痛或关节炎(60%),肌痛(40%),腹痛(20%),肝脾肿大(13%)。除关节痛和肌痛较为常见外,余与文献报告的相近似。本报告实验室检查示ESR升高(80%),贫血(40%),白细胞增多(27%),白细胞减少(40%),血小板减少(7%),低补体(50%),可检出7S IgM(60%)。循环免疫复合物升高(50%)亦与文献报告相类似。组织学特征:间隔性脂膜炎(64%),小叶性脂膜炎(92%),含脂质的吞噬细胞(85%)。其它发现包括纤维化,坏死及血管炎;组织学改变与文献报道的相似,但
The authors reported and analyzed 15 patients with Weber-christian disease (WCD) and compared them with 253 reported in the literature. Clinical features: The average age was 42 years, 12 women and 3 males. Subcutaneous nodules (92%) in both lower extremities or subcutaneous nodules (60%) in both upper extremities, fever (80%), arthralgia or arthritis (60%), myalgia (40%), abdominal pain (20%), Hepatosplenomegaly (13%). In addition to joint pain and muscle pain more common, I and the literature similar. Laboratory tests in this report show elevated ESR (80%), anemia (40%), leukocytosis (27%), leucopenia (40%), thrombocytopenia (7%), and low complement 7S IgM out (60%). Increased circulating immune complexes (50%) are also similar to those reported in the literature. Histological features: Intermittent panniculitis (64%), lobular panniculitis (92%), lipid-containing phagocytes (85%). Other findings include fibrosis, necrosis and vasculitis; histological changes are similar to those reported in the literature, but