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目的:探讨硝酸咪康唑与伊曲康唑对于外阴阴道假丝酵母菌病的治疗效果,评价其临床应用价值。方法:将2010年12月-2011年12月在我服务中心进行治疗的76例外阴阴道假丝酵母菌病患者随机分为两组。对照组38例患者给予硝酸咪康唑治疗;观察组38例患者给予伊曲康唑治疗。对两组的治疗有效率进行比较。结果:对照组患者在治疗后一周及四周的有效率分别为81.6%(31/38)和71.1%(27/38);观察组患者在治疗后一周及四周的有效率分别为97.4%(37/38)和92.1%(35/38),观察组患者在治疗后一周及四周的有效率均高于对照组,两组间差异具体统计学意义(P<0.05)。结论:伊曲康唑治疗外阴阴道假丝酵母菌病的效果好于硝酸咪康唑,有效率较高,具有很好的临床应用价值。
Objective: To investigate the therapeutic effect of miconazole nitrate and itraconazole on vulvovaginal candidiasis and to evaluate its clinical value. Methods: 76 cases of vulvovaginal candidiasis who were treated in our service center from December 2010 to December 2011 were randomly divided into two groups. Thirty-eight patients in the control group were treated with miconazole nitrate; in the observation group, 38 patients were given itraconazole. The effectiveness of treatment was compared between the two groups. Results: The effective rates in the control group were 81.6% (31/38) and 71.1% (27/38) respectively one week and four weeks after treatment. The effective rates in the observation group one week and four weeks after treatment were 97.4% (37 / 38) and 92.1% (35/38) respectively. The effective rate of the observation group was higher than that of the control group one week and four weeks after treatment. The difference between the two groups was statistically significant (P <0.05). Conclusion: The efficacy of itraconazole in the treatment of vulvovaginal candidiasis is better than that of miconazole nitrate, with high efficiency and good clinical value.