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原发性肺黏液腺癌(mucinous adenocarcinoma,MA)为肺浸润性腺癌亚型,临床少见,其发病机制尚不明确。本文基于K-ras突变状态探讨肺MA的发病机制及K-ras突变与临床病理特征的关系。作者从2 474例原发性肺腺癌的手术切除标本中选择其中诊断为MA 45例(2.1%)进行分析。其中,男性19例,女性22例。22例(48.9%)有K-ras突变,7例(15.6%)有EGFR突变,2例K-ras及EGFR均有突变。
Primary mucinous adenocarcinoma (MA) is a subtype of pulmonary infiltrating adenocarcinoma, which is rare in clinical practice. Its pathogenesis is not yet clear. In this paper, based on the K-ras mutation status of pulmonary MA pathogenesis and K-ras mutation and clinicopathological features. The authors selected from 2474 cases of primary lung adenocarcinoma resected specimens of whom 45 cases were diagnosed as MA (2.1%) for analysis. Among them, 19 males and 22 females. 22 (48.9%) had K-ras mutations, 7 (15.6%) had EGFR mutations and 2 had K-ras and EGFR mutations.