This paper puts forward a novel concept, the spatial flow influence factor (SFIF), which provides a new insight into the airflow structure. This concept is very helpful in the control of indoor air pollutants since: (1) for a given indoor airflow and given sources of volatile organic compounds (VOCs), the optimal arrangement of the VOC sources can easily be obtained; (2) for given positions of VOC sources and occupied regions (or target regions), the optimal indoor airflow pattern or organization can be determined; (3) the SFIF for an indoor space can also be regarded as the indoor air safety index of that space. To illustrate this concept, we present several examples of applying a SFIF to indoor air VOC control.